General Information

  • ID:  hor000047
  • Uniprot ID:  O15240
  • Protein name:  VGF-derived peptide TLQP-62
  • Gene name:  VGF
  • Organism:  Homo sapiens (Human)
  • Family:  VGF family
  • Source:  Human
  • Expression:  Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
  • Disease:  Diseases associated with VGF include Vaccinia and Pheochromocytoma.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0003674 molecular_function; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0008083 growth factor activity
  • GO BP:  GO:0001541 ovarian follicle development; GO:0002021 response to dietary excess; GO:0006091 generation of precursor metabolites and energy; GO:0007165 signal transduction; GO:0009409 response to cold; GO:0019953 sexual reproduction; GO:0030073 insulin secretion; GO:0032868 response to insulin; GO:0033500 carbohydrate homeostasis; GO:0042593 glucose homeostasis; GO:0042742 defense response to bacterium; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0050804 modulation of chemical synaptic transmission; GO:0051591 response to cAMP; GO:0099538 synaptic signaling via neuropeptide
  • GO CC:  GO:0005615 extracellular space

Sequence Information

  • Sequence:  TLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP
  • Length:  62(554-615)
  • Propeptide:  MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK
  • Signal peptide:  MKALRLSASALFCLLLINGLGA
  • Modification:  T24 Proline amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Enhanced synaptic activity;Effects on spontaneous excitability of superficial dorsal horn neurons;Antidepressant effects;Spinal plasticity;Long-term memory formation
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9QZQ3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9QZQ3-F1.pdbhor000047_AF2.pdbhor000047_ESM.pdb

Physical Information

Mass: 859151 Formula: C323H513N111O97
Absent amino acids: CDFKMW Common amino acids: ER
pI: 7.91 Basic residues: 16
Polar residues: 8 Hydrophobic residues: 16
Hydrophobicity: -150.48 Boman Index: -24945
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 66.29
Instability Index: 15605.16 Extinction Coefficient cystines: 4470
Absorbance 280nm: 73.28

Literature

  • PubMed ID:  31878142
  • Title:  TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling